CANINE MENINGIOMA: COMPARISON OF PALLIATIVE THERAPY, SURGERY AND STEREOTACTIC RADIOSURGERY
Introduction
Meningiomas represent about half of primary intracranial tumours in dogs. There are limited comparative studies regarding the various treatment modalities. The aim of this study was to compare palliative therapy, surgery and stereotactic radiosurgery in canine meningioma.
Methods
The data was collected retrospectively from 198 dogs referred to one institution over a 15-year period with histopatologically confirmed or MRI consistent with meningioma. Dogs were grouped by anatomical site (supratentorial – E, infratentorial – T, spinal – S) and by therapeutic option (palliation – P, surgery – S, radiosurgery – R). The surgery goal was a total resection of tumour. LINAC based VMAT radiosurgery was performed in 1 – 5 fractions. Serial clinical and MRI examinations were conducted. Signalment, clinical signs, neuroanatomical tumour location, relapse specifics, adverse events, best response and overall survival (OS) time were evaluated. The OS estimates were calculated using the Kaplan-Meier method and the differences between compared groups using log-rank analysis. Multivariate analysis was performed using Cox regression.
Results
91 dogs (51 E, 33 T, 7 S) had been palliated, 69 dogs (33 E, 31 T, 5 S) had been treated with stereotactic radio-surgery, 38 dogs (32 E, 1 T, 5 S) with surgery. OS in PE was 190 days, in PT 38 days, in PS 89 days, in RE 781 days, in RT 654 days, in RS 813 days, in SE 567 days, in ST 3 days, in SS 210 days. The predictive variables of OS are localisation and therapy option.
Conclusion
Conclusion
The dogs suffering from meningioma undergoing stereotactic radiosurgery had superior results comparing with those treated with surgery or palliation.
